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The most frequently reported side effects of tirzepatide are gastrointestinal in nature: nausea, mild stomach discomfort, decreased appetite, and occasionally constipation or diarrhea
This effect seems to be dose-related, as patients receiving 5 mg daily showed a mean reduction of about 100 cells/mcL, and those receiving 2.5 mg daily did not have a decrease in lymphocyte count
Gastrointestinal distressnausea, vomiting, constipationis most frequent, especially early on
Your body adapts to the mechanism of action, and while the therapeutic appetite suppression continues, the unpleasant side effects resolve
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